yes u can, but there will be some loss of horsepower, other than that u're ok.
Premium
Use 91 octane or higher octane rating premium gas for the 2009 Lexus RX350
Gas like water H2O is better to use and run smooth with it. :-)
The 2010 Lexus IS-350 is a gas-powered vehicle.
The 2010 Lexus IS-F is a gas-powered vehicle.
The 2010 Lexus IS-250 is a gas-powered vehicle.
The 2010 Lexus GX-460 is a gas-powered vehicle.
The 2010 Lexus RX-350 is a gas-powered vehicle.
The 2010 Lexus IS-250-C is a gas-powered vehicle.
The 2010 Lexus LS-460 is a gas-powered vehicle.
The 2010 Lexus LX-570 is a gas-powered vehicle.
The 2010 Lexus IS-350-C is a gas-powered vehicle.