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Yes, low hemoglobin can cause muscle pain. Hemoglobin is a protein and is attached to red blood cells. Its job is to carry oxygen to the body's tissues. Without oxygen the tissues (including muscle) experience ischemia which is painful. Ischemia is what causes the pain a person has when they have a heart attack, for instance. So if a person's red blood cells are not carrying oxygen (because their hemoglobin levels are low enough), they would have muscle pain.

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