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i assume you're asking why it happens. opiates (like oxycodone) are direct mast cell degranulators. the mast cells 'degranulate' and release histamine which makes you itch. usually benadryl (or other antihistamines) help the itching, but be careful when combining sedatives...
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∙ 15y ago
Wiki User
∙ 14y agoIt actually is pretty likely but there's plenty of chance that it won't.
Benadryl might help with the itch.
Wiki User
∙ 13y agoIf oxycodone makes you itch from head to toe, it means you are allergic to the medicine or one of the compounds in the pill.
Wiki User
∙ 13y agoIt sounds like you are having an allergic reaction. Discontinue use and call your doctor.
Wiki User
∙ 12y agonope that's normal
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