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You pretty much don't. I suppose it may be possible at some astronomical dosage measured in kilograms instead of milligrams, but I can't begin to guess where you'd find that, nor how it would kill you without your vomiting it up.

Alprazolam has its dangers, but lethality is not apparently one of them. The LD50 (Lethal Dose for 50% of the test group) measured in mg/kg, comes out to pounds of the stuff. Overdoses tend to induce intense sleep or coma, but not death.

*every human being is different, and whether they die from an overdose of Xanax would depend on the person's age, health status, weight, and many other variables. There is much research currently being studied in earnest regarding why some human beings die at a "non-toxic" level of a medication while others do not. If a person is on any other medications, including Over the Counter and mixing these meds with the Xanax, that could have a large effect on the outcome.

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9y ago
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Q: Can someone kill himself with Xanax?
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