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When Ambien is combined with any CNS depressant, which includes alcohol, it will increase the effects of that depressant. Therefore, great care and caution must be exercised whenever mixing ambien with any CNS depressant, including percocet. Talk to your doctor because, if there is a need to mix the two, then the dosages will have to be modified to prevent their additive effect.

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16y ago
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14y ago

My father just overdosed with both these drugs in his system. It's a very dangerous drug to mix with something else. Please do not make the same mistake he did. I will always be hurt from the loss of him. I can not explain the pain I feel.

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15y ago

You can check all known interactions of drugs yourself with the website http://www.drugs.com/drug_interactions.php. Simply type in the drugs you wish to find and select the correct drug from the dropdown menu. All known interactions will then appear.

---- Interactions searched:

* Ambien (zolpidem) * OxyContin (oxycodone) ---- 1 Interaction found:

# OxyContin (oxycodone) and Ambien (zolpidem) (Moderate Drug-Drug) PROBLEM: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

POSSIBLE SOLUTION: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

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11y ago

Yes you can, as my doctor prescribes me both to take together, and the pharmacist has said it is safe as well.

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12y ago

At recommended theraputic doses, yes it is safe to take both. At very high doses it could potentially lead to severe respiratory depression and ultimately death.

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14y ago

Yes you can mix them as long as your taking a moderate dose of each. the effects will hit you harder so take less of both than you normally would

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