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No. The R-101 was made in caliber .22 LR, which is a very different round from the .22 WMR. Later models of the High Standard Sentinel WERE made in .22 Mag, but if YOUR sidearm is not marked .22 Magnum or .22 WMR, do NOT try to fire them in it.

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13y ago
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Q: Can you shoot 22 mag in a hi standard r-101?
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