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I hope so because I just did! Tramadol is classified as an analgesic, having both weak opioid properties and weak SNRI properties. Naltrexone will displace tramadol on the mu-2 opioid receptors, blocking pain relief through that pathway. However, studies have confirmed that the fast acting SNRI properties of tramadol will still provide significant pain relief compared to placebo when taken with an opiate antagonist such as naltrexone. Studies in myself have confirmed these findings. To the best of my knowledge, this is not a dangerous combination.

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