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This will depend on the type of allergic reaction (mild rash vs. anaphylaxis) and the risk / benefit analysis of the prescriber. Generally, azithromycin (Zithromax) would be avoided in a patient with previous allergic reaction to erythromycin, but there may be rare circumstances where the potential benefit outweighs the potential risk if the previous reaction was mild, or if the patient can be monitored for a reaction and immediately given supportive treatment.

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14y ago

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