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No, you do not want to take two antihistamines together. You should not need both of them. If Zyrtec is not working for you, it's probably time to see your doctor for a prescription antihistamine. Taking too much antihistamine can sedate you too much, and you might pass out or have trouble breathing.

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Jasen Runte

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Q: Can you take Zyrtec and Benadryl together?
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As a pharmacy doctorate candidate I would say that it is not recommended to give Zyrtec and Benadryl together since they will both relieve allergy symptoms in similar ways. Zyrtec is best if you want non-drowsy relief. Benadryl would be best if you want the child to sleep. Both however, are effective.


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I asked my doctor this same question. She says it's not advisable, but if your Allergies are very bad, you can take Zyrtec in the morning, and then Benadryl before bed. Zyrtec makes some people drowsy (although not me) and Benadryl makes most people drowsy, so mixing them can put you to sleep. Zyrtec dries out your system, as well, so drink extra water. Don't do this too often. Too much antihistamine can be bad for you, but doing this occasionally is okay.


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