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Both medications are prescribed/taken together, but since the Benadryl is OTC, you should check with your doctor or pharmacist. If you are taking the Benadryl because you have gotten a rash from taking the amoxicillin, stop taking the amoxicillin and report the reaction!! You will need to insert a medical alert in your records that you have had an allergic reaction to amoxicillin...which means you will not be able to take any other member of the penicillin family: Augmentin, Cloxapen, Trimox, Bactocil, Veetids, etc..
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