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Nyquil contains Tylenol plus a cough suppressant and doxylamine, an antihistamine. Since Allegra is also an antihistamine, these would overlap in indication. Pharmacists prefer taking individual products so as to avoid interactions and duplications of ingredients, so try taking plain Tylenol and Robitussin DM with the Allegra and skip the Nyquil.

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15y ago
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9y ago

You probably should not take them together at the same time.

Nyquil contains diphenhydramine- an antihistamine that works in much the same way as Allegra (fexofenadine).

The diphenhydramine in Nyquil is what causes both the drowsiness and the drying up effect.

If you are taking Allegra, you probably should not need Nyquil, because they are very similar in effect. (Allegra causes dryness in much the same way, but less drowsiness)

Take one or the other, but not both together.

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Q: Can you take Allegra D and any cold medicine together?
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