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You can, and it is a commonly prescribed combination, however great care needs to be taken. Flexeril greatly increases the effects of Percocet, and as such, the chances of the user having undesirable side effects. These commonly include a change in level of consciousness (unresponsive to questions, unable to communicate effectively) or in breathing. Consult a doctor before taking either drug, or both together.

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Q: Can you take Percocet and Flexeril together?
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