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Yes. Many cold remedies are a combination of these two drugs (usually also including detromethorphan, a cough suppressant).

Guafenesin is an expectorant--it loosens phlegm or mucus making it easier to cough up.

Sudafed is a brand name for pseudoephedrine, the decongestant that appears to be the most effective. In the U.S., however, pseudoephedrine has become a "restricted" product not because of the intended use as a decongestant but because some people used it to make homemade methamphetamine, a dangerous drug (meth or crystal meth). For that reason, products with pseudoephedrine (like sudafed) often have to be purchased from "behind the counter"--you have to request that a pharmacist gets it for you and they may ask you to sign a log showing that you bought it and how much. THis is only so that any large purchases (for meth use) can be spotted easily by drug crime investigators.

So sudafed is safe and effective in most people, although of course there are side effects to watch for. And it can be combined with expectorant (guafenesis) or cough suppressants (detromethorphan).

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15y ago
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14y ago

Yes, these would be OK. Taking an antihistamine along with an expectorant can help clear the mucus out of your lungs. Remember to increase your water intake to help break up the mucus and cough it out. Guaifenesin can also make you jittery or nervous.

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Q: Can I take guaifenesin and Flonase?
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