Can you use cheat engine 6.0 on league of legends?

Answer 1

Not in the way you are thinking, no. All the data used for your gold and level or anything that would affect how you interact with other players or the store, including the IP and RP are all stored on the LOL servers, and not on your computer.

You can use it, but you won't be able to change anything significant, it is also against their terms of service so they might delete your account. You could probably mess up the way some things look to you, and you might be able to hack the way colors are represented to see heroes better or something, but the only thing you'll be able to change is the way you see things, it won't have any way to game the system to get 100,000 gold or anything.

The game is server-sided so anything you change on your client is not seen by others so if you try to use gold-hack and buy an item, when the client responds to the server, it will not work. However, you can mod the client to add custom skins and map textures but those will only be seen by you.