Cell death caused by perforin and granzymes is caused by?
I think it may be caused by CTLs
Cytotoxic T-cells kill infected cells in one of two ways: 1. By interaction with Fas ligand on T-cell with Fas molecule on target cell (induces apoptosis). 2. Release of lytic granules containing granzymes (also induces apoptosis) - For this, the T-cell needs to form pores in the target cell using perforin and granulysin.
A division of your immune system called cell mediated immunity is charged with stopping viral infections. The main actors of that are called cytotoxic T cells who, when they encounter a cell that is displaying viral antigens on its surface, binds to the cell and releases toxic substances called perforins and granzymes that destroy and digest the viral infected cell.