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Induced fit: is a more recent theory which suggests that the substrate attaches to the enzyme in a relatively accurate fit, then the enzyme moulds around it, then continues the chemically complex reaction.
Lock and Key Mechanism: As obvious as the name states, the lock and key model is simply the substrate fitting acutely into the enzyme with no adjustments required to the enzyme.
K.G. ;)
Wiki User
∙ 13y ago
Wiki User
∙ 14y agoWhat is the fit model of enzyme activity?
Wiki User
∙ 13y agosubstrate goes into activity site
gets lulzed
and come out with 2 serperate molecules.
Wiki User
∙ 13y agoThe binding of the substrate changes the shape of the enzyme's active site.
Wiki User
∙ 10y agoIt moves the reactive portion of the enzyme closer to the substrate. The enzyme's active site changes shape to fit the correct substrate but not other molecules.
Wiki User
∙ 13y agoLysozyme
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What is the difference between the lock and key model versus the induced fit model of the enzyme substrate complex?
The lock and key model means that the substrate must perfectly fit the enzyme, and the enzyme does not change. The induced fit model is different as when the substrate fits together with the enzyme, the enzyme itself will change to either join substrates together or break a substrate down.
What is enzyme-substrate specificity?
It means that an enzyme will only work on one specific substrate at a time, because no meaningful biochemical activity can occur without their absolute specificity.We are talking about 30,000 bio-enzymatically controlled Biochemical reactions.In the Chem Lab a product yield of 60 percent is a huge achievement.In the Body anything less than a 100 percent yieldwould swiftly result in the Cell being overwhelmed by the useless by-products of these 30,000 biochemical Reactions.
What is the meant by the lock and key hypothesis?
The lock is the equivalent to that of an enzyme while the key is portrayed as the substrate. Like an enzyme, the lock can be reused many times as it remains chemically unchanged at the end of the reaction. Also, the fact that reactions occur only at the active site, or binding site, is showed as the key only being able to open the lock only at the keyhole, not anywhere else. The hypothesis also shows the fact that enzymes can only catalyse a specific substrate, showed as the lock, only being able to open with a specific key. Firstly,the substrate will enter the active side of the enzyme.then,the enzyme will change it shape slightly as the substrate binds.During this time,the substrate will be broken down.After that,the product will leave the active sides of the enzyme.
Lock and key method?
In biology the lock and key method states that an enzyme and it's substrate are complementary and only the correct substrate can bind with the enzyme, this is due to the folding in the protein structure. However this theory is outdated and the inducted fit method is a much better representation.
What is the active site of an enzyme?
The most important part of the enzyme- where the chemical reactions happen. Substrates fit into the active site and are broken down or catalysed into end products (this is called the lock and key model).
What is a induced fit hypothesis?
a. The substrate can be altered so it is induced to fit into the enzyme's active site. b. The enzyme changes its shape slightly as it binds to the substrate. c. The enzyme is altered so it is induced to fit many different types of substrate. d. Several sites on an enzyme can be induced to act on a substrate.
What is a change in the shape of an enzyme allowing it to react effectively with a substrate is a what?
An induced fit is a change in the shape of an enzyme which allows it to react effectively with a substrate. The reason for the alteration is to speed up a chemical reaction.
What is the difference between the lock and key model versus the induced fit model of the enzyme substrate complex?
The lock and key model means that the substrate must perfectly fit the enzyme, and the enzyme does not change. The induced fit model is different as when the substrate fits together with the enzyme, the enzyme itself will change to either join substrates together or break a substrate down.
Is the active side of an enzyme highly changeable portion of an enzyme that adapts to fit the substrates of various reactions?
When an enzyme binds to the appropriate substrate, subtle changes in the active site occur. This alteration of the active site is known as an induced fit.Induced fit enhances catalysis, as the enzyme converts substrate to product.Release of the products restores the enzyme to its original form. The enzyme can repeat this reaction over and over, as long as substrate molecules are present.
How does an enzyme recognize its substrate?
On one part of an enzyme is an active site (which is what the substrate binds to) that is shaped a certain way, say a triangle. A substrate that's in the shape of a square won't fit onto the triangle/the enzyme - but a substrate that has an indent in the shape of a triangle will. The way an enzyme recognizes its substrate is if it can attach itself to the enzyme's active site.
What type of model does an enzyme work like?
enzymes work on lock and key model and induced fit model.
What happens if enzymes loose their specificityAsk us anything?
They can't catalyse reactions. The specificity of the active site of the enzyme is crucial: without it, the enzyme won't fit with he desired substrate, hence there won't be any reaction. Losing this specificity is due to a conformational change at the active site, andis known as denaturisation.
The specificity of an enzyme is due to its active siteThe active site is a shape only a certain?
An enzyme's active site will bind with only a specific substrate. Any other kind of substrate will be rejected by the active site.
Why is the Induced fit model better than the lock and key model?
induce fit model is better because it causes a change in the enzyme active sit and allows the substrate to fit in
As an enzyme fits into a substrate at the active site it undergoes a slight change in order to fit into the substrate. this process is defined by a concept called?
This concept is called an induced fit.
How does the induced fit model help to explain non-competitive inhibition?
The induced fit model is the theory that instead of enzymes and substrates fitting exactly together, as in the lock and key model, the enzyme changes shape around the substrate to bind with it. Non-competitive inhibition is where the inhibitor does not fit into the active site, but into another site on the enzyme instead, which changes the shape of the active site.
Define the enzyme-substrate complex?
The theory of enzyme-substrate complex was established by Michaelis and Menton in 1913.According to their theory,enzyme combines with substrate to form enzyme-substrate complex.The transient complex has a lower energy of activation than that of substrate alone.This results in the acceleration of the reaction.The enzyme-substrate complex is broken down into enzyme and products of the reaction. E+S -ES - - -ES - - -E+P The different hypotheses of enzyme-substrate complex formation have been postulated.Early theory was postulated by Emil Fischer.According to this theory,the catalytic site of enzyme is preshaped to fit of the substrate.This hypothesis is called "lock and key" or rigid template.The next hypothesis has been proposed by Koshland in the late 1950s.The hypothesis was called "induced fit".Acccording to this theory,a catalytically active configuration of enzyme molecule and that of the active site can be induced only at the moment of attachment of the substate molecule,that is the substrate induces a conformotional change in the enzyme. At the present time,model of "induced fit" is modified.Binding the substrate with the enzyme leads not only to the conformational change of the protein molecule,but also to a geometrical and electrontopographic rearrangement of the substrate molecules. The modern "induced fit" hypothesis presumes the existence between the enzyme and the substrate of not only spatial or geometrical complementarity,but also electrostatic charge complementarity.
