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Lions have a number of predators, one of the main predators being man. Lions are used for trophy hunting and hunted and poisoned by farmers who have lost stock to lions. Lions don't really have natural predators although in the course of hunting can be injured or killed by some animals they hunt such as buffalo, giraffe and zebra, who have powerful horns or hooves. There is a long association with lions and hyena who have been described as eternal enemies. Hyena and lion will each attack and kill the other if the opportunity arises, however they do not eat from the carcass as they would with prey animals. Disease from introduced livestock and domesticated animals can also effect lions

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