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I believe it makes the antibiotic not work as well.
Editd by johnv714 to improve answer:
According to James Steckelberg, MD, of the Mayo Clinic, the effects of combining antibiotics and alcohol can vary, depending on the specific antibiotic. Alcohol doesn't noticeably diminish the effectiveness of some antibiotics. However, antibiotics and alcohol can cause similar side effects, such as stomach upset, dizziness and drowsiness. When you combine antibiotics and alcohol, these side effects may increase.
A few antibiotics - such as metronidazole (Flagyl), tinidazole (Tindamax) and trimethoprim-sulfamethoxazole (Bactrim) - should not be mixed with alcohol because this may result in a more severe reaction. Drinking any amount of alcohol with these medications can result in side effects such as flushing, headache, nausea and vomiting, and rapid heart rate. Keep in mind that some cold medicines and mouthwashes also contain alcohol. So check the label and avoid such products while taking these antibiotics.
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