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The World Health Organization certified the eradication of smallpox in 1979. Earlier during the 20th century smallpox claimed the lives up up to half a billion people.

Since the only smallpox virus samples left remain in US and Russian bioweapon laboratories, the answer is no, global warming has no impact on smallpox. However, were weaponized strains to be released, the warmer temperatures would help accelerate the spread of the disease.

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