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No, it should not (especially if you are referring to the condom and not the oral contraceptive pill). This may be related to the CYP3A4 enzyme that is responsible for slowly breaking down many drugs and toxins in our body, with the OCP (oral contraceptive pill) being one of the affected drugs. This ensures that the drug levels (and of course toxin levels) do not stay in our bodies permanently. However grapefruit juice is an inhibitor of the enzyme, and as such it slows down the breakdown of the contraceptive in the body. By applying the double negative makes a positive rule, you'll understand that this would cause the effect of the drug to be "stronger" instead. However this does not mean that women should take less OCPs and more grapefruit juice if they want to prevent pregnancy, this "stronger" effect only happens in some drugs, but has yet to be proven in OCPs. St. John's Wort, which is available over the counter on the other hand is a CYP3A4 inducer, and that has the opposite effect in causing the OCP to be broken down faster, so it has been proven in some clinical trials that women on both should approach their doctor for advise on tailoring their OCP dosage, else be at higher risk of unexpected pregnancy

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