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It depends where it is in a sentence. At the beginning of a sentence, it is followed by a comma and should be preceded by a period or semi-colon--it is a conjunctive adverb, not a conjunction, though the error of treating it so is so common that it may eventually be accepted. . At the end of the sentence, it is generally preceded by a comma. In the middle of a sentence, it usually has commas at both ends. It is not set off by commas when modifying an adjective--e.g., "however false he may be"--though the phrase or clause it is a part of may be set off--e.g., "However false he may be in general, he is speaking the truth this time."

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15y ago

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