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You can but... I know there may be a depressed respiratory system issue when combining these two drugs. You wont want to be taking them long term together anyway, since sleep inducing drugs and codeine mixed will impair you, inhibiting your normal life. With that all said: I am taking a very reduced dose of trazodone to get to sleep tonight since the Tylenol #3s wear off in four hours and I'm not interested in waking up in the middle of the night with severe pain ( dental surgery yesterday) but I am highly sensitive to trazodone, I rarely take it.

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13y ago
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14y ago

No it does not.

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Q: Can you take Tylenol with codeine and trazodone together?
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