About 3 hours, depending on traffic around SF.
www.mapquest.com
About 225 miles.
It will require about 3.5 hours of driving time to travel that 216.32 miles according to MapQuest.
like 4 hours if you take the 505/winters cutoff
the driving time from San JOse to San Francisco is about 1 hour.
South
The driving time from San Diego to San Francisco is 8 hours and 1 minute.
The approximate driving time and mileage information - Between: San Francisco, CA and: Redding, CA Driving miles: 215 Driving time: 3 hrs 30 mins - is based on traveling non-stop in good driving conditions. Driving time does not take into consideration conditions which may extend travel time such as weather, road work, border crossings, and rush hour traffic in urban areas. Mileage denotes actual road miles covered as opposed to Point A to Point B linear distances on a map.
The distance between the starting point and the destination is 215mi, (396km), and will take approximately 3 hours 17 minutes of driving time.
About 8 hours.
By car, it's about 215 miles.
Google Maps estimates the driving time as 4 hours and 39 minutes.