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Pure oxygen is very harmful to humans at pressures higher than ground level, with the effects becoming worse the higher the pressure - ie. when Scuba diving.

At lower pressures, such as the cockpit of a plane at altitude, pure oxygen becomes much safer to breathe, to the point some astronauts have breathed it for around 2 weeks (at low pressure) with no detrimental effects.

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Q: Explain why the pilot can breathe pure oxygen without negative side effects?
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