The correct statement about the prevention of immune attack on self is that the immune system has mechanisms in place, such as central and peripheral tolerance, to distinguish between self and non-self antigens. Central tolerance occurs during T and B cell development to eliminate self-reactive lymphocytes, while peripheral tolerance mechanisms like regulatory T cells help control any self-reactive immune responses that may develop later. Dysfunction in these tolerance mechanisms can lead to autoimmune diseases where the immune system attacks self antigens.
The lack of reactivity of T cells and B cells to your own proteins is known as self-tolerance. It is an important mechanism to prevent the immune system from attacking the body's own tissues. If self-tolerance is disrupted, it can lead to autoimmune diseases.
Genes within the Major Histocompatibility Complex (MHC) region, such as HLA genes in humans, code for self proteins responsible for presenting antigens to the immune system. These proteins play a crucial role in distinguishing between self and non-self cells and are essential for immune response regulation and self-tolerance.
Guido Kroemer has written: 'Mechanisms of immunological self-tolerance' -- subject(s): Immunology, T-Lymphocytes, Autoimmunity, Immunological tolerance, B-Lymphocytes, Immune Tolerance
In 1954 Medawar went on to prove that immune tolerance was acquired during an embryo's development. Injection of foreign substances into embryonic or newborn mice would produce permanent tolerance to those substances later in life. In other words, the mouse's body would forever recognize such a substance as "self," instead of responding to it as a foreign invader in need of destruction by the immune system.
Histocompatibility antigens, also known as human leukocyte antigens (HLAs), help the immune system recognize and distinguish between self and non-self cells by serving as markers on the surface of cells. These antigens play a crucial role in immune responses by allowing the immune system to identify and target foreign invaders while avoiding attacking the body's own cells.
Sir Frank Macfarlane Burnet was Director of the Walter and Eliza Hall Institute of Medical Research, Melbourne 1944-1966. In 1960 he (with P. Medawar) was awarded the Nobel Prize for the discovery of acquired immunological tolerance. His work influenced the later developments of DNA sequencing. KateNatashaQ Hope it Helped! :)
1. Your immune system can recognize cells based on the proteins present on the surface of cells. Viruses, bacteria, and other foreign cells are recognized as being different from your own cells and are attacked by your immune system.
The immune system is usually non-reactive against "self" antigens under normal conditions.
When we don't love ourselves
Body cells have self markers, or proteins, located on their surface that help the immune system identify them as part of the body and not foreign invaders. These self markers are unique to each individual and aid in distinguishing between self and non-self cells. When the immune system detects cells without these self markers, it may initiate an immune response to target and eliminate those foreign cells.
If you have an an inflammatory form of arthritis like for example RA it is the immune system that is attacking your joints and you need to treat it by suppressing the immune system to a degree. you would be wise to check with your doctor what treatments are best for you to self administer in any case.