How can you avoid buildup of positive pressure when reconstituting antineoplastics?

Answer 1

There are two ways to avoid positive

pressure.

1. The first way is to allow air to escape from the vial at

the same time you inject a drug or diluent. Inject small

amounts, little by little, and allow the air from the vial

to enter the syringe.

2. The second way to prevent aerosolization of drug is to

use a chemo safety pin. These pins prevent a drug from leaving by positive pressure. Spike the pin into the drug vial. Thepressure will escape into the pin area rather than

through the needle. You'll filter out any aerosolized

drug in the diaphragm of the chemo safety pin.

Answer 2

To avoid the buildup of positive pressure when reconstituting antineoplastics, slowly inject the diluent into the vial and allow time for pressure to equalize. Use a larger syringe for injections to increase the rate of reconstitution. Avoid using excessive force or shaking the vial vigorously, which can create pressure.