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Answered 2007-01-06 02:44:02

DEPO side effects will clear up within 2-3 months while pregnancy symptoms will continue. If you suspect you may be pregnant you need to have a blood test. Both cause an absence of menstruation, most women will have no menses the entire time they are on Depo (after the first few months of spotting/irregular bleeding). With pregnancy you will have nausea and breast tenderness, which are not usually present while on Depo.

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