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To replace the thermostat in a 2010 Mercedes Benz C300, first ensure the engine is cool and disconnect the negative battery terminal. Drain the coolant and remove the engine cover if necessary. Then, locate the thermostat housing, disconnect the hoses, and unbolt the housing to access the thermostat. Replace the old thermostat with a new one, reassemble the housing, reconnect the hoses, and refill the coolant before starting the engine to check for leaks.

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