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Once MAME is installed and you have some roms in the proper folder, right click the desktop or start menu Icon and select to run as Administrator. You might have to also go to the compatability tab and select to run the program under Windows XP service pack 2 or 3.
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More details would be needed for a correct fix, but... You might have to run the mame program under administrator privilages. Vista is a quirky operating system. It's safer than XP, but a bit harder to control because of the safeguards. Try right clicking the mame program shortcut and select, "run as administrator". See if that works.
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