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Intact skin is our bodies' largest organ and our most important defense against pathogens. Pathogens cannot directly pass through skin, thus severely restricting the ways that pathogen can enter the body to the facial features, excretory system and open wounds. Therefore, the best method to stopping pathogens from entering the body is to prevent exposure of the possible entrances to pathogens. For the facial features, the easiest method is to keep your hands clean (since they are the most likely body part to come in contact with your eyes, mouth, and nose). For the excretory system (anus, vagina, penis), keep those areas clean. For open wounds, sanitize and cover.

The spreading of pathogens to others follow the same concept. They only have a finite amount of exits. As long as others do not come in contact with your bodily fluids, the likelihood of transfer is very low.

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