Increasing release of dopamine
Chantix is a non-nicotine medication used for adults that are tryinq to stop smoking. It targets nicotine receptors in the brain and reduced release of dopamine compared to nicotine.
Chemical Receptors
The "substance" binds itself to the dopamine receptors and tricks the brain into believing it is receiving messages from dopamine.
Drugs act on the neurons in the reward pathway of the brain. Drugs increase the release of dopamine.
nicotine is a chemical that acts on nicotinic acetlycholine receptors, which are neurotransmitters in the brain. nicotine also releases dopamine, a reward system chemical ... it also acts as an MAOI inhibitor, monoamine oxidase breaks down other neurotransmitters such as dopamine, serotonin and norepinephrine. so it acts on alot of chemicals, some directly and some indirectly by inhibiting the breakdown of the neurotransmitters.
Anti psychotic medication is used to treat schizophrenia, bipolar disorder, and various other conditions. It works by blocking dopamine receptors in the brain, meaning that the effects of dopamine are lessened.
The theory behind why individuals develop 'psychotic' symptoms is based upon the idea that there are elevated levels of dopamine in the brain. Dopamine is a neurotransmitter, a molecule that passes messages between neurons. For example, when a nerve impulse arrives at a dopaminergic neuron (also known as a pre-synaptic neuron), dopamine is released from the cell and diffuses through a space between two neurons, called the synaptic cleft. Dopamine then binds to specific dopamine receptors on a different neuron (post-synaptic neuron) producing a specific signal, impulse or effect. Dopamine is then released from its receptors and 're-absorbed' into the pre-synaptic neuron, or degraded by enzymes in the synaptic cleft. The neuroleptics block dopamine receptors thereby inhibiting the ability of dopamine to attach to these receptors and generate signals. However, unlike the typical neuroleptics, the atypicals merely transiently block the receptors therefore allowing some dopamine to bind to the receptors and generate signals. The atypical neuroleptics are also able to block serotonin receptors located on dopaminergic neurons. When serotonin binds to these receptors it inhibits dopamine release. However as these receptors are blocked by atypical neuroleptics, the dopamine secretion is increased. The transient rather than permanent blocking of dopamine receptors and the blocking of serotonin receptors and subsequent increases in dopamine, it is for these reasons that the atypicals are thought to produce fewer adverse effects than the typical neuroleptics. However, the atypical drugs differ in their 'stickyess' when binding to dopamine receptors and also in the ratio of which dopamine ad serotonin receptors are affected. This may result in some atypicals producing higher levels of specific adverse effects than others. The atypicals may also bind to other receptor types, producing further adverse effects (see side effects of atypicals section).
Keith Allen Wreggett has written: 'Brain dopamine receptors, multiple sites or states'
I am assuming you are talking about marijuana so..... There are cannabinoid receptors in your brain. THC is a cannabinoid which blocks the receptors, causing dopamine to flood your brain. This is why marijuana highs are associated with a general feeling of well-being. THC affects the sensory and reaction pathways in your brain.
Dopamine is the major neurotransmitter of the reward circuit in the central nervous system. It also functions in movement and balance, among other things. It is a chemical found in the human brain that creates feelings of pleasure.
Well, the reason you're not very angry, or sad when high on weed is because when you smoke it increases the amount of Dopamine let out of the Dopamine Receptors. What is Dopamine? Dopamine is a chemical in your brain, whenever you're in a good mood, dopamine is released from the receptors, weed speeds the amount of dopamine released drastically. Dopamine is responsible for pleasure such as eating and sex. About being resistant to pain, I'm not quite sure and am unable to find anything online, but I'm about 80% positive it has something to do with dopamine.
As far as we know, dopamine is the main culprit in psychosis. Autospies have shown excess dopaminergic receptors in the brain's of people who suffered psychosis. Other neurotransmitters are also affected.