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Smallpox was an infectious disease caused by either of two virus variants, Variola major and Variola minor. Smallpox localized in small blood vessels of the skin and in the mouth and throat.
In the skin it resulted in a characteristic maculopapular rash and, later, raised fluid-filled blisters. V. major produces a more serious disease and has an overall mortality rate of 30-35%.
Long-term complications of V. major infection include characteristic scars, commonly on the face, which occur in 65-85% of survivors. Blindness resulting from corneal ulceration and scarring and limb deformities due to Arthritis and osteomyelitis are less common complications, seen in about 5% of cases.

The history of smallpox extends into pre-history; the disease likely emerged in human populations about 10,000 BC. The earliest credible evidence of smallpox is found in the Egyptian mummies of people who died some 3,000 years ago.
During the 18th century the disease killed an estimated 400,000 Europeans each year, including five reigning monarchs, and was responsible for a third of all blindness. Between 20 and 60% of all those infected, and over 80% of infected children, died from the disease.


During the 20th century, it is estimated that smallpox was responsible for 300-500 million deaths.

In the early 1950s an estimated 50 million cases of smallpox occurred in the world each year. As recently as 1967, the World Health Organization estimated that 15 million people contracted the disease and that two million died in that year.
After successful vaccination campaigns throughout the 19th and 20th centuries, the WHO certified the eradication of smallpox in December 1979. To this day, smallpox is the only human infectious disease to have been completely eradicated.

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Can Chickenpox spread on the skull as well?

While chickenpox lesions will not affect the bony skull, lesions on the scalp are common. You may also get bumps on the face.


Is chickenpox bad?

Yes, it is a disease that affect mostly children. Refer to link below.


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Chickenpox is caused by varicella zoster virus, a member of the herpes family. And chickenpox can affect the mucous membranes near the eye. However, chickenpox does not cause the kind of vision-threatening infection usually associated with herpes simplex or herpes zoster infection of the eye.


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Yes. The only thing I am aware of that remotely might be related to your question is that if someone has sickle cell anemia they are unlikely to get malaria.