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First off, how long cocaine remains in the body depends upon a number of factors: doage, duration of usage, & metabolism (i.e., someone who is overweight will not metabolism & eliminate the drug & its metabolites from the body as quickly). With that said, insufflated (or snorted) cocaine has a half life of roughly 1 hour; & its psychoactive effects last anywhere from 10 minutes to 40 minutes. Other ways of using cocaine will eliminate it from the body even quicker- IV use will leave the body the quickest--and its effects are shorter in duration as well--followed by smoking cocaine (i.e., either freebasing or by using crack-cocaine) , which is slightly longer acting, around 5-15 minutes tops.

Relative to IV'd heroin and/or other potent opiates/opioids, death from cocaine-overdose is very rare (although this is not to say severe side effects from overdose wont occur, such as convulsions and/or seizure). But to answer your question: Someone who uses cocaine daily w/ a moderate tolerance (an eight of an ounce, or less, per day) generally can "speedball" within 2-3 hours after using cocaine. Although it is recommended to "speedball" around 4-5 hours after last use. Someone who is a social user of cocaine, well, he or she should be okay speedballing 1.5-3 hours after last use.

However, it is pertinent to note that polydrug use is very dangerous. If you overdose on one of the substances & need medical attention- antagonists are unsafe to use.. i.e., if naloxone is used for a heroin overdose, this may cause exasperated cocaine effects--including, but not limited to, seizure, unconsciousness, and possible death (especially in heroin/opiate tolerant users). So please be careful, heroin quality can differ between batches (and frankly how much faith you have in your dealer... b/c TRUST ME, they could care less about your health; they only care about their ends, being profit). Before using both substances at once, I would recommend using one of them first (particularly heroin, since it is more likely to cause coma or death from overdose) before you decide to speedball or engage in polydrug use (i.e., combined two or more drugs, usually "hard drugs", at once.

Good luck and please be safe... Among users of hard drugs (such as meth or amphetamines, cocaine or crack-cocaine, heroin or other potent opiates/opioids like fentanyl or hydromorphone, GHB, alcohol, and/or barbiturates) around 3% of users die every YEAR (that is, 3 users out of every 10) as a result of their drug use. PLEASE use caution!

And this equally applies to insufflation of heroin; not just injecting it--unless I specifically referred to intravenous injectionl

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11y ago
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10y ago

like 10 min should be fine.

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Q: How long afterusing cocaine can you use heroin without the risk of speed-balling?
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