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Theoretically, as soon as the patch was removed (though some residual nicotine will remain dissolved in the subcutaneous tissues after it is removed), but the patch should not be taken on and replaced whenever the urge to smoke arises. In this case, a higher strength patch needs to be used. If the current patch is already at the 21 mg strength, a combination approach using the patch plus either Chantix or Wellbutrin/Zyban would be a more rational approach to smoking cessation.

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Q: How long can i smoke after you take off the nicotine patch?
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