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The length of time on a medication/drug which may cause tolerance and dependence is relative to the dose and the regularity with which the drug is taken.

For instance, a patient might be prescribed clonazepam 0.5 mg daily when anxious and end up using it two or three times per week. On this basis, a lifetime of use would not be too long.

However, if clonazepam is used at the level of 2 mg three times per day, every day, then tolerance and dependence could occur after just a few weeks.

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