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Five minutes.

It will reach the brain in seconds but the result is not seen promptly until it reaches adequate concentrations in the brain cells. THC is highly lipid soluble and takes a while to spread out in the fatty tissue. It also takes a while to be excreted (30 days or so). This is why MJ smokers get picked up so easily on urine tests.

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Q: How long does it take THC to reach the brain when inhaled?
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