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To the point of lethality; major organ failure could still be treated successfully. However, if you wait that long, it is likely they would already be dead. There is no set time for every person, just as there is no set dose that would exactly cause overdose.

If you know someone has overdosed on acetaminophen, you need to take them to the emergency Room, call poison control, or at the very, very least, call a pharmacist (there are many 24 hour pharmacies to call). This is a serious, potentially life-threatening condition.

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Q: How long does it take before an acetaminophen overdose can't be treated?
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