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The driving distance between Kansas City, MO and St. Louis, MO is approximately 250 miles. The driving time would be approximately 4 hours 15 minutes if you were to travel non-stop in good driving conditions. (The driving time does not take into consideration conditions which may extend trip time such as weather, road work, border crossings and rush hour traffic in urban areas.)

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Q: How long is the drive from Kansas City Missouri to st louis Missouri?
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