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What is the bioavailability of a drug?
Bioavailability of a drug refers to the fraction of the administered dose that reaches systemic circulation in an unchanged form. It is a measure of the extent and rate at which the active ingredient is absorbed and becomes available at the site of action in the body. Bioavailability is influenced by factors such as route of administration, drug formulation, and first-pass metabolism.
Can a drug which is 100 percent absorbed from GI tract have 100 percent bioavailability?
No, a drug that is 100 percent absorbed from the gastrointestinal (GI) tract would not necessarily have 100 percent bioavailability. Bioavailability is affected by factors such as first-pass metabolism in the liver, which can reduce the amount of the drug that reaches the systemic circulation unchanged. Thus, even if a drug is fully absorbed, its bioavailability may be less than 100 percent.
What is a tympanic route?
A tympanic route refers to administering medication through the ear canal, which can bypass the need for oral administration. This method is often used for rapid drug delivery in emergency situations where other routes are not accessible.
How does chemical stability of the drugs in the gastrointestinal tact affect the bio-availability of the drugs?
Bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, so we need chemically stable drug in order to increase the chance of drug absorbance and thus increased bioavailability.
What effect did administration of saline injections have on the control rat?
Administration of saline injections had no pharmacological effect on the control rat since saline does not contain any active drug. The control rat would not experience any physiological changes or behavioral effects from receiving saline injections.
What is bioavailability?
Bioavailability is the amount of drug which reaches the site of physiological activity after administration.
What is the bioavailability of a drug?
Bioavailability of a drug refers to the fraction of the administered dose that reaches systemic circulation in an unchanged form. It is a measure of the extent and rate at which the active ingredient is absorbed and becomes available at the site of action in the body. Bioavailability is influenced by factors such as route of administration, drug formulation, and first-pass metabolism.
What is bioavilability in pharmacology?
Bioavailability in pharmacology refers to the fraction of a drug that reaches the systemic circulation and is available to produce an effect after administration. It is typically expressed as a percentage and takes into account how much of the administered dose is absorbed and becomes available to the body. Factors like drug formulation, route of administration, and first-pass metabolism can affect a drug's bioavailability.
Is oral route of administration safer?
Yes the oral route for drug administration is the safest route.
What is 'first pass mechanism' in pharmacology?
In pharmacology, the first-pass mechanism refers to the initial metabolism of a drug in the liver before it reaches systemic circulation. This process can significantly reduce the bioavailability of the drug, meaning less of the drug reaches its target site in the body. It is an important consideration when determining drug dosage and route of administration.
Which of the is not a gi tract route of drug administration?
Topical administration is not a gastrointestinal tract route of drug administration. It involves applying medication directly to the skin or mucous membranes for localized effects.
Is there a correlation between routes of administration of drugs and drug actions?
Yes, the route of administration can significantly change the amount of drug absorbed and the potency of the drug.
What is the difference between an injection that is given IM OR IV?
IM means Intramuscular route of drug administration, while IV means Intraveinal route of drug administration. IV route, takes the drug directly into the bloodstream resulting in 100% bioavailability instantly. Where as in IM route, drug is injected into muscle tissues, which holds the drug for a while and gradually releases into the bloodstream through the network bed of capillaries running across or surrounding the muscle tissue. In IM, the bioavailability may be slightly less than 100% of drug due to diffusion from muscle through tissue fluid and into the blood.
What is the route of administration of a drug that is placed between gum and cheek?
buccal
Bio availabilty has a better feature when it gets dissolved or undissolved?
Bioavailability measures the amount of a drug (medicinal) or other substance which enters the blood. This depends on two types of factors: 1) The physical and chemical properties of the drug. If a drug is insoluble (ie does not dissolve) in the stomach or intestine it is unlikely to be absorbed into the blood, so its bioavailability will be low. If it is soluble it is more likely to be absorbed so its bioavailability will be high. 2) The route in which it is given. Direct injection into the blood gives 100% bioavailability. Taking a drug by mouth is likely to give less than 100% bioavailability. For more details see: http://www.merck.com/mmpe/sec20/ch303/ch303c.html
What is a bioequivalence?
A bioequivalent is a formulation of a drug which is equivalent to some other formulation in terms of bioavailability.
Process that brings a drug from the administration site into the blood stream is called?
The process that brings a drug from the administration site into the bloodstream is called absorption. It refers to the movement of a drug from its site of administration into the bloodstream for distribution throughout the body. Factors such as route of administration, drug formulation, and physiological properties can affect drug absorption.
