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How zymogens are activated?

Updated: 8/11/2023
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13y ago

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proteolytic cleavage

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11y ago
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Q: How zymogens are activated?
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What is the pancreatic enzyme that activates the zymogens?

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The acinar cells of the pancreas secrete proteolytic enzymes as zymogens or proenzymes. These enzymes are in their inactive form and must be activated by something else. One of these enzymes, trypsinogen, is activated by enterokinase found in the cells that make up the duodenum wall. Once activated to trypsin, it activates the other digestive enzymes.


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Pancreatic enzymes aren't "activated" until they reach the small intestine. If they're activated just after they're produced, pancreatitis can result as the enzymes try to digest the pancreas. Pancreatitis is very painful and often fatal. I have a cat with chronic pancreatitis who has to take steroids, probiotics, nutritional supplements, and antibiotics. Pancreatic enzymes aren't "activated" until they reach the small intestine. If they're activated just after they're produced, pancreatitis can result as the enzymes try to digest the pancreas. Pancreatitis is very painful and often fatal. I have a cat with chronic pancreatitis who has to take steroids, probiotics, nutritional supplements, and antibiotics.


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