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Not unless the Pok�mon you would be trading has a hexidecimal ID that is not filled in the receiving game. Example: if you were to trade a Missingno. or M-Block from R/B/Y to G/S/C, the Missingno. will be replaced by a Pok�mon with the corresponding HD code, usually a Remoraid or Tyrogue. In short, NO.

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Q: If you trade a Pokemon you caught with a Game Shark to another Pokemon game does it mess it up?
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