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In sickle cell disease, a single nucleotide variation in the HBB gene, which codes for the beta-globin subunit of hemoglobin, leads to the substitution of valine for glutamic acid at the sixth position of the beta-globin chain. This mutation causes hemoglobin to polymerize under low oxygen conditions, resulting in the distortion of red blood cells into a sickle shape. These sickle-shaped cells can obstruct blood flow, leading to pain, organ damage, and increased risk of infections. Ultimately, this genetic variation significantly impacts the overall health and lifespan of affected individuals.
What else can I help you with?
In sickle cell disease variation in one gene causes red blood cell to bend or sickle. This means the sickle cells?
Cannot carry normal levels of oxygen to cells :) *NovaNet*
What common genetic variation which causes a change in the amino acid sequence in the structure of hemoglobin leads to what disease?
Sickle cell
In sickle-cell disease variation in one gene causes red blood cells to bend or sickle. This means the sickled cell?
Cannot carry normal levels of oxygen to cells :) *NovaNet*
In sickle-cell disease variation in one gene causes red blood cells to bend or sickle. This means sickle cells?
Cannot carry normal levels of oxygen to cells :) *NovaNet*
In sickle-cell disease variation in one gene causes red blood cells to bend or sickle. This means the sickled cells .?
Cannot carry normal levels of oxygen to cells :) *NovaNet*
In sickle-cell disease variation in one gene causes red blood cells to bend or sickle. This means the sickled cells.?
Cannot carry normal levels of oxygen to cells :) *NovaNet*
Did tiki barber have the sickle cell disease?
No, Tiki Barber does not have sickle cell disease. He is a retired NFL player who has been very active in various charitable causes, but sickle cell disease is not one of the health conditions he has publicly discussed.
Is sickle cell disease a blood cancer?
No, sickle cell disease is not cancerous.
Is you kiss do you get sickle cell disease?
No. Sickle Cell is not an infectious disease, but is genetic.
How does disease affect the cell?
Sickle cell disease is a mutation in the gene that codes for hemoglobin, which causes the hemoglobin and the cell to become elongated and look like a sickle rather than its normal disc shape.
What is the word for the genetic disorder that causes abnormal hemoglobin is known as?
sickle cell anemia. If you are only heterozygous for this disease it is simply called sickle trait.
What are other names for sickle cell anemia?
Hemoglobin SS disease (Hb SS)
