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It's effect at the -receptors in the central nervous system is said to be responsible for analgesia, euphoria, dependence potential and respiratory depressions. Morphine also binds with k-receptors which mediate spinal analgesia, miosis and sedation. The major effects of morphine are on the central nervous system and the bowel. Opioids act as agonists, interacting with stereospecific and saturable binding sites or receptors in the brain and other tissues.Morphine is about two-thirds absorbed from the gastrointestinal tract with the maximum analgesic effect occurring 60 minutes post administration.

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