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It's definitely not a completed answer but here is what I found: "Prednisone is rapidly converted to prednisolone in the liver and in most instances, these drugs are considered to be roughly equivalent." The above quote is from the website linked below.

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Q: Is pregnenolone similar to prednisolone
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What is the precursor to all steroid hormones?

pregnenolone


Is pregnenolone a male hormone?

Pregnenolone is formed in the human body from cholesterol, and is the precursor of both male and female hormones. So it is not specifically a male hormone.


What are the conditions that warrant the use of prednisolone?

Prednisolone is a drug that acts in a similar fashion to the hormone cortisol; its primary effect is to modulate and down-regulate the immune system, although there are numerous side effects as well. In general, prednisolone is indicated to control excessive immune reactions such as auto-immune disease or in short term cases, such as to control excessive scratching.


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Pregnenolone must be avoided while while pregnant or breastfeeding. Sometimes it can cause anxiety, acne, facial hair growth and negative mood changes.


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4 mg methylprednisolone is equivalent to 5 mg prednisolone.


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Pregnenolone was first used in the 1940's as a treatment for arthritis, to ease the swelling of joints and inflamation. It is now also used as a treatment for memory loss, attention loss, mood disorders, PMS and stress


Is tobramycin ophthalmic solution and prednisolone acetate ophthalmic suspension USP the same?

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Is Prednisolone a controlled substance?

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