The active ingredient in Nyquil is a common antihistamine that chears the head and promotes sleep. An occasional use to help one sleep is not a big deal. However, the chemical is not without its side effects, and no sleep aid should be used regularly. Otherwise one may become unable to sleep without help.
The best natural aids to sleep are exercise, good nutrition (including a small high-protein snack before bedtime), avoiding caffeine for 6 hours before bedtime and getting to bed at the same time every night. Meditation can help calm a busy mind, too.
I've mixed NyQuil (when sick, not for recreational use) and unisome before (unisome is like ambien or lunesta) as well as Nyquil and the prescription sleeping med Trazidone. As long as you take them at the right dosages, and check up to make sure its not a specifically bad chemical reaction, you should be fine. Just be careful that the Nyquil doesn't already have some of what is in the sleeping medicine, (example: acetaminophen of about 600mg is common in most nyquil and sleep aid products, make sure you don't take anything else with acetaminophen... which is not in sleep aids but simply as an example) You should be fine. :)
Mainly drowsiness, blurred vision, trouble concentrating. Nothing bad and or life threatining unless your allergic to Nyquil, or have another medication that reacts with it. There aren't any drugs that react bad with marijuana. You might not need the nyquil if you smoke marijuana first, that normally does it for me.
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