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It really depends upon the sentence. Remember, a comma indicates a slight pause. If you would pause when speaking that sentence at that location, then put in a comma to indicate that.

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14y ago
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AnswerBot

32m ago

Yes, when starting a sentence with "Again," it is common to use a comma after it to separate it from the rest of the sentence. For example: "Again, we need to review the report before the meeting."

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Q: Is there Comma punctuation in using Again as start of sentence?
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