Yes. There is no shortage of examples. Perhaps the mos infamous is the Tri-State tornado of 1925, which left nearly 700 people dead.
The Waco, Texas tornado killed 114 people.
27 people were killed.
The Daultapur-Saturia tornado of 1989 killed an estimated 1,300 people.
The Tri-State tornado killed 71 people in Indiana
The Oklahoma City tornado of May 3, 1999 killed 36 people.
The Andover tornado killed 17 people.
The Tri-State tornado killed 695 people.
The Joplin, Missouri tornado of May 22, 2011 killed 158 people. This ranks it as the 7th deadliest tornado in U.S. history.
158 people were killed by the Joplin tornado. Another tornado on the same day killed 1 person in the Minneapolis area.
If you are referring to the Bridgeport, Connecticut tornado, none were killed by the tornado itself. 3 People were killed in other storm-related events.
The Moore, Oklahoma tornado of May 20, 2013 killed 24 people. A tornado in Shawnee, Oklahoma the day before killed 2 people.
There were no tornado related deaths in Kansas in 2000.