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Aspirin is generally produced by the following mechanism (starting from basic materials) Phenol --(NaOH, CO2, heat)--> Sodium Salicylate (+para isomer) --(H2SO4)--> Salicylic acid --(acetic anhydride)--> acetylsalicylic acid (Aspirin) Due to the myriad of organic reactions, there are multiple possibilities at each stage. However, the above is the most efficient and common way of synthesizing Aspirin. For example, the last reaction (esterification) may be accomplished by using an acyl halide instead of an anhydride (e.g. ethanoyl/acetic chloride instead of acetic anhydride). However, the acyl halide is more costly to synthesize and more unstable to handle.
What else can I help you with?
Is aspirin synthesis an exothermic reaction?
yes
What is the mechanism of absorption of aspirin and alcohol in stomach?
diffusion
What is the mechanism of drug interaction of aspirin to children?
24 hours
Why pyridine is used im the synthesis of aspIrin?
Pyridine is used in the synthesis of aspirin as a catalyst to help facilitate the esterification reaction between salicylic acid and acetic anhydride. Its basic properties help neutralize the acidic byproducts formed during the reaction, which improves the yield of aspirin. Additionally, pyridine can also help dissolve the reactants and promote the formation of the desired product.
What is the purpose of phosphoric acid in the synthesis of aspirin?
Phosphoric acid is used in the synthesis of aspirin as a catalyst to facilitate the esterification reaction between salicylic acid and acetic anhydride. It helps increase the reaction rate and yield of aspirin.
What is mechanism and action of indomethacin?
a prostaglandin (PGE2) synthesis inhibitor
Is aspirin synthesis an esterification reaction?
No, aspirin synthesis is not an esterification reaction. It involves the reaction of salicylic acid with acetic anhydride to form acetylsalicylic acid (aspirin) and acetic acid through an acetylation reaction. Esterification typically involves the reaction of an alcohol with a carboxylic acid to form an ester.
Is Ibuprofen aspirin based?
No. Ibuprofen is derived from propionic acid. Aspirin is acetylsalicylic acid. However, they are both drugs known as NSAIDs and have a common mechanism of action in the body.
What is an alternative reagent to ethanoic anhydride in the synthesis of aspirin from salicylic acid?
Synthesis of acetyl chloride via the reaction of acetic acid with sulphuric acid
How will you convert phenol into aspirin?
Aspirin (acetyl salycilic acid) is prepared from salycilic acid and acetic anhydride; salicylic acid is prepared from sodium phenoxide and carbon dioxide (Kolbe synthesis).
Aspirin works to reduce the symptoms of infection or pain by retarding the synthesis of?
Certain Eicosanoids--M.S. Exercise Physiology
During synthesis of aspirin which bonds break and which new bonds form?
During the synthesis of aspirin, the bonds that break are the ester bonds in acetic anhydride and salicylic acid. New bonds that form are ester bonds between the acetyl group and the hydroxyl group of salicylic acid to produce aspirin.
