Etodolac is a class of NSAIDs, are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Etodolac blocks the enzyme that makes prostaglandins.
prostaglandins
Stool (poo) is the chemical substance produced by the body that is associated with the pain of inflammation, as inflammation is pain in your backside.
Certain hormones such as prostaglandins may be released. These hormones enhance the pain message and play a role in immune system responses to injury, such as inflammation.
prostaglandins
As per http://ask.bmezine.com/2008/06/14/mensuration-lowered-pain-threshold/, " It is down to the presence of prostaglandins which play a part in the sloughing off of the womb lining. Unfortunately for us, prostaglandins make the nociceptors (pain receptors) in the brain more sensitive. As a point of interest, if you suffer from bad period pains you will be more sensitive to pain around this time in general, as the worse the cramps, the higher the level of prostaglandins. "
Leukocytes and macrophages exposed to foreign substances secrete pyrogens such as interleukin-1, leading to the increased production of prostaglandins in the hypothalamus. These prostaglandins inhibit warm temperature-sensing neurons within the hypothalamus. The firing of cold temperature-sensing neurons hence increases to increase the body temperature resulting in fever.
It causes more prostaglandins to flood the brain
Prostaglandins have a wide variety of effects, and may be responsible for the production of some types of pain and inflammation
The inflammatory substance responsible for pain during menstruation is prostaglandins. The prostaglandins cause the uterine contractions, but in high quantities it will cause blood vessels supplying the uterus with blood to construct so starve the uterus of blood/oxygen very temporarily, and thus this is what causes the pain during menstruation.
Kinins and prostaglandins are both key cells in the process of inflammation. Active complement or tissue damage can trigger these mast cells. The Kinins trigger pain in the nerve endings. Prostaglandins are like histamine and increase permiability and vasodilation in the capillary vessel. Which is the most important part of the inflammation process.
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