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NyQuil already contains doxylamine, which is almost exactly like Benadryl (diphenhydramine), so it wouldn't be a good idea to take them together since that would be a "duplication of therapy". If the NyQuil isn't keeping your congestion down, you could probably take 25 mg of Benadryl (diphenhydramine) and be OK.

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13y ago

What else can I help you with?